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Cross-presentation of glycolipid from tumor cells loaded with alpha-galactosylceramide leads to potent and long-lived T cell mediated immunity via dendritic cells. Glycolipid antigen induces long-term natural killer T cell anergy in mice. Cell Rep. Download references. You can also search for this author in PubMed Google Scholar. SP and GL designed the experiment, analyzed the data, and wrote the manuscript. SC and AM performed the experiments.
All authors read and approved the final manuscript. Correspondence to Girdhari Lal. All animal experiments were performed as per the NCCS approved protocol. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Figure S1. Figure S2. Figure S3. NK cell depletion abolishes the -GalCer-induce inhibition of tumor growth. Figure S4. Gating strategy for M1- and M2-macrophage analysis. Figure S5. PDF kb. Reprints and Permissions. Paul, S. Download citation. Received : 07 March Accepted : 30 July Published : 06 August Anyone you share the following link with will be able to read this content:.
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Skip to main content. Search all BMC articles Search. Download PDF. Abstract Background NKT cells play an important role in anti-tumor immunity. Introduction Natural killer T NKT cells show the characteristics of innate as well as adaptive immune cells. Isolation and staining of cells Single cell suspension was prepared as described earlier [ 26 ]. Intracellular cytokine staining Intracellular cytokine staining was performed as described earlier [ 26 ].
In vivo depletion of NK1. Full size image. Discussion NKT cell is a group of unique lymphocytes that are capable of recognizing lipid antigens presented by CD1d molecule. References 1. PubMed Article Google Scholar Google Scholar Article Google Scholar Acknowledgments We thanks Dr.
Padma Shastry for critical reading, suggestions, and comments on the manuscript. View author publications. Consent for publication Not applicable. Competing interests The authors declare that they have no competing interests. Additional file. Additional file 1: Figure S1. About this article. Cite this article Paul, S. J Immunol 4 — NKT cell subsets as key participants in liver physiology and pathology.
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